Sneha first commercial success was in her Tamil film Aanandham, which was the second film in her career.
Sneha almost acted all the Tamil Actors like Kamal, Vijay, Ajith, Vikram, Surya, Simbu, Dhanush, Srikanth etc except Rajni.
She has acted in several Tamil, Telugu, Malayalam and Kannada language films.Sneha has won two Filmfare Award for Best Supporting Actress for her performance in Unnai Ninaithu (2002)and Autograph (2004) and has been nominated thrice for a Filmfare Best Actress Award.